Current design splits the Tranches based on mapping boundaries of generalization:
- tranche 1 - generalization to unseen screens - CRC PDO lines
- tranche 2 - specific mechanisms - ER+ patient-derive xenograft organoids
- tranche 3 - prospective experiments
A similar approach mapping boundaries in oncology would split by cancer types
- tranche 1 - tissue type - sarcomas
- tranche 2 - tissue type - pancreatic
- tranche 3 - primary vs. metastatic
- tranche 4 - mutation subtypes across tissue
- tranche 5 - agressive subtypes
- etc
Current design splits the Tranches based on mapping boundaries of generalization:
A similar approach mapping boundaries in oncology would split by cancer types